Baton Rouge Back Pain Related to Inflammation Reduced with Melatonin

Inflammation. Disc Degeneration. There is a connection. Inflammation acts as the body’s response system to damaging stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it attempts to restore itself to normal before the harm was done. Capitol Spine & Rehabilitation is always amazed at how the body takes care of itself! Capitol Spine & Rehabilitation sees its Baton Rouge chiropractic care as a partner of the body’s system in healing especially when spine pain is an issue. Chiropractic care uses many tools like spinal manipulation, exercise, and nutrition to take care of the body. Melatonin is one nutritional tool that is proving value in its ability to interrupt the inflammatory process related disc herniation that results in back pain, neck pain and other spine related pain.

DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'

Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are related to intervertebral disc degeneration. (1) IL-1 β in fact promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body controls itself down to the cellular level via autophagy, the natural process during which the body’s cells clean out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin enhanced autophagy and reduced the degradation of the disc’s extracellular matrix (technically marked by a decrease in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The final conclusion was that melatonin inhibits intervertebral disc degeneration by stimulating autophagy. (3) Wow. Capitol Spine & Rehabilitation is encouraged by this research to see just how well melatonin can perform for Baton Rouge back pain related to disc degeneration.

MELATONIN AND ITS HEALING WAYS FOR THE DISC

Disc degeneration is quite a common malady seen at Capitol Spine & Rehabilitation making positive news like this quite rousing. A new study stated that melatonin could modulate the extracellular matrix of the disc remodeling process started by IL-1 β. Additionally, melatonin reduced the inflammatory cell collection and reduced the release of connected inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding that melatonin disrupted the IL-1B feedback loop, researchers postulated that melatonin may contribute to the healing process of intervertebral discs after damage was already present. (1) Capitol Spine & Rehabilitation will keep following the new research regarding the role inflammation plays in Baton Rouge disc degeneration and melatonin’s role in reducing it.

INFLAMMATION AND MELATONIN

The significance of melatonin in helping to slow or stop painful conditions due to inflammation is rising. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other things is quite fitting. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by hindering the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland secretes melatonin naturally. Melatonin impacts the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) activities. (1) Melatonin’s specific effect on inflammation and disc degeneration is most interesting to Capitol Spine & Rehabilitation and our Baton Rouge back pain patients.

CONTACT Capitol Spine & Rehabilitation

Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she describes how The Cox® Technic System of Spinal Pain Management addresses disc degeneration for relief of chronic low back pain in her patient.

Schedule your Baton Rouge chiropractic appointment with Capitol Spine & Rehabilitation now. We can discuss how inflammation affects your back pain and how melatonin may address the related disc degeneration.

 
Capitol Spine & Rehabilitation shares new findings that melatonin interrupts the inflammatory process in disc degeneration that causes back pain. 
 
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